Overview

  • Product nameAnti-Cirhin antibody
    See all Cirhin primary antibodies
  • Description
    Rabbit polyclonal to Cirhin
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the N-terminal region of Human Cirhin.

  • Positive control
    • Neuro-2a cell line lysates and Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab103357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 77 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • RelevanceDefects in Cirhin are the cause of North American Indian childhood cirrhosis. NAIC is a severe autosomal recessive intrahepatic cholestasis, originally described in Ojibway-Cree children from northwestern Quebec. NAIC typically presents with transient neonatal jaundice, in a child who is otherwise healthy, and progresses to biliary cirrhosis and portal hypertension. Biochemical and histopathological features suggest involvement of the bile ducts rather than of the bile canaliculi. They include elevated gamma glutamyltransferase and alkaline phosphatase levels, and, typically, marked fibrosis around bile ducts. Clinically, NAIC is distinct from other nonsyndromic familial cholestases because of its marked cholangiopathic features and severe degree of fibrosis on liver histology.
  • Cellular localizationNucleus; nucleolus
  • Database links
  • Alternative names
    • CIRH1A antibody
    • Cirhin antibody
    • Cirrhosis, autosomal recessive 1A (cirhin) antibody
    • FLJ17146 antibody
    • KIAA1988 antibody
    • NAIC antibody
    • testis expressed gene 292 antibody
    • TEX292 antibody
    • UTP4 antibody
    • UTP4 small subunit (SSU) processome component homolog antibody
    see all

Anti-Cirhin antibody images

  • Anti-Cirhin antibody (ab103357) at 1/100 dilution + Neuro-2a cell lysate at 35 µg

    Predicted band size : 77 kDa
  • IHC analysis in formalin fixed and paraffin embedded Human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining, using ab103357 at a dilution of 1/50.

References for Anti-Cirhin antibody (ab103357)

ab103357 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"