Overview

  • Product namecis-PPDA
  • Description
    GluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist
  • Biological descriptionPotent GluN2C/GluN2D (formerly NR2C / NR2D)-preferring NMDA receptor antagonist. (Ki values for recombinant rat receptors are 0.096 (NR2C), 0.125 (NR2D), 0.55 (NR2A) and 0.31 μM (NR2B)).
  • Purity> 98%

Properties

    References for cis-PPDA (ab120047)

    This product has been referenced in:
    • Kinarsky L  et al. Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket. J Pharmacol Exp Ther 313:1066-74 (2005). Read more (PubMed: 15743930) »
    • Morley RM  et al. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem 48:2627-37 (2005). Read more (PubMed: 15801853) »
    • Lozovaya NA  et al. Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J Physiol 558:451-63 (2004). Read more (PubMed: 15146049) »

    See all 4 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"