Overview

  • Product name
  • Description
    Rabbit polyclonal to CIT
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of Human CIT.

  • Positive control
    • Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab110897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

Target

  • Relevance
    CIT is a putative RHO/RAC effector that binds to the GTP bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. This protein exhibits dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. CIT plays an important role in the regulation of cytokinesis and the development of the central nervous system.
  • Cellular localization
    Cytoplasmic
  • Database links
  • Alternative names
    • Citron (rho interacting serine/threonine kinase 21) antibody
    • Citron antibody
    • Citron Rho interacting kinase antibody
    • CRIK antibody
    • EC 2.7.11.1 antibody
    • KIAA0949 antibody
    • Rho interacting serine/threonine kinase 21 antibody
    • Rho interacting serine/threonine protein kinase 21 antibody
    • serine/threonine-protein kinase 21 antibody
    • STK2 antibody
    • STK21 antibody
    see all

Images

  • ab110897, at a 1/50 dilution, staining CIT in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

References

This product has been referenced in:

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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