Citalopram, 5-HT reuptake inhibitor (ab120133)
Key features and details
- 5-HT reuptake inhibitor
- CAS Number: 59729-32-7
- Soluble in water to 10 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Citalopram, 5-HT reuptake inhibitor -
Description
5-HT reuptake inhibitor -
Biological description
Selective serotonin reuptake inhibitor. Antidepressant in vivo.
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CAS Number
59729-32-7 -
Chemical structure
Properties
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Chemical name
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide -
Molecular weight
405.30 -
Molecular formula
C20H21FN2O.HBr -
PubChem identifier
77995 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Br.CN(C)CCCC2(OCc1cc(ccc12)C#N)c3ccc(F)cc3 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab120133 has been referenced in 5 publications.
- Burke DA & Alvarez VA Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens. Cell Rep 39:110795 (2022). PubMed: 35545050
- Collins HM et al. Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice. J Psychopharmacol 36:794-805 (2022). PubMed: 35607713
- Unger EK et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183:1986-2002.e26 (2020). PubMed: 33333022
- Podkowa K et al. Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495. Neuropharmacology 111:169-179 (2016). PubMed: 27569995
- Howerton AR et al. Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation. J Neurosci 34:7113-23 (2014). PubMed: 24849347