Anti-CK1 epsilon antibody (ab70110)

Overview

• Product nameAnti-CK1 epsilon antibody
  See all CK1 epsilon primary antibodies
• Description
  Rabbit polyclonal to CK1 epsilon
• Specificityab70110 detects endogenous levels of total CK1 epsilon protein.
• Tested applicationsSuitable for: WB, ELISA, IHC-P, ICC/IFmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic peptide derived from an internal sequence of human CK1 epsilon

• Positive control
  • LOVO cell extracts, HeLa cells and human placenta tissue.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab70110 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • Other Kinases

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Placenta (human) normal tissue slides (ab4360)

Applications

Target

• FunctionCasein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation.
• Tissue specificityExpressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
• Sequence similaritiesBelongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
  Contains 1 protein kinase domain.
• Post-translational
  modificationsAutophosphorylated.
• Cellular localizationCytoplasm. Nucleus.

• Target information above from: UniProt accession P49674 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 1454 Human
  • Entrez Gene: 27373 Mouse
  • Omim: 600863 Human
  • SwissProt: P49674 Human
  • SwissProt: Q9JMK2 Mouse
  • Unigene: 474833 Human
  • Unigene: 30199 Mouse
• Alternative names
  • Casein kinase 1 epsilon antibody
  • Casein kinase I antibody
  • Casein kinase I epsilon antibody

  • Casein kinase I isoform epsilon antibody
  • CKI epsilon antibody
  • CKI-epsilon antibody
  • CKIe antibody
  • CKIepsilon antibody
  • CSNK 1E antibody
  • CSNK1E antibody
  • DBT antibody
  • Doubletime, Drosophila, homolog of antibody
  • EC 2.7.11.1 antibody
  • epsilon isoform antibody
  • HCK IE antibody
  • KC1E antibody
  • KC1E_HUMAN antibody
  • kinase CK1 epsilon antibody
  • MGC 10398 antibody

  see all