Overview

  • Product nameAnti-CLACP antibody
    See all CLACP primary antibodies
  • Description
    Rabbit polyclonal to CLACP
  • Specificityab65159 detects endogenous levels of total CLACP protein.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of human CLACP.

  • Positive control
    • Jurkat and A549 cell extracts.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab65159 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab65159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/20000.
WB 1/500 - 1/1000. Detects a band of approximately 65 kDa (predicted molecular weight: 65 kDa).

Target

  • FunctionInhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
  • Tissue specificityExpressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
  • Sequence similaritiesContains 7 collagen-like domains.
  • Post-translational
    modifications
    Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component.
    Glycosylated.
    Hydroxylated on 11% of proline residues and 49% of lysine residues.
  • Cellular localizationMembrane. After proteolytic cleavage, CLAC is secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alzheimer disease amyloid associated protein antibody
    • Alzheimer disease amyloid-associated protein antibody
    • AMY antibody
    • CLAC antibody
    • CLAC P antibody
    • CLAC precursor antibody
    • CLAC-P antibody
    • Col25a1 antibody
    • COL25A1 protein antibody
    • Collagen alpha 1 XXV chain antibody
    • Collagen alpha 1(XXV) chain antibody
    • Collagen like Alzheimer amyloid plaque component antibody
    • Collagen like Alzheimer amyloid plaque component precursor antibody
    • Collagen type XXV alpha 1 antibody
    • Collagen-like Alzheimer amyloid plaque component antibody
    • Collagenous Alzheimer amyloid plaque component antibody
    • COPA1_HUMAN antibody
    see all

Anti-CLACP antibody images

  • All lanes : Anti-CLACP antibody (ab65159) at 1/500 dilution

    Lane 1 : Jurkat cell extract
    Lane 2 : A549 cell extract
    Lane 3 : A549 cell extract with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 65 kDa
    Observed band size : 65 kDa
    Additional bands at : 23 kDa,34 kDa,45 kDa,50 kDa,90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-CLACP antibody (ab65159)

ab65159 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"