Overview

  • Product nameAnti-CLASP1 antibody
    See all CLASP1 primary antibodies
  • Description
    Mouse monoclonal to CLASP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: DGLAKHPPPF SQPNSIPTAP SHKALRRSYS PSMLDYDTEN LNSEEIYSSL RGVTEAIEKF SFRSQEDLNE PIKRDGKKEC DIVSRDGGAA SPAT, corresponding to amino acids 1133-1227 of Human CLASP1

Properties

Applications

Our Abpromise guarantee covers the use of ab58105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMicrotubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
    • Sequence similaritiesBelongs to the CLASP family.
      Contains 7 HEAT repeats.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle. Golgi apparatus > trans-Golgi network. Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.
    • Information by UniProt
    • Database links
    • Alternative names
      • 1700030C23Rik antibody
      • 5730583A19Rik antibody
      • B130045P17Rik antibody
      • CLAP1_HUMAN antibody
      • clasp1 antibody
      • CLIP associating protein 1 antibody
      • CLIP associating protein CLASP1 antibody
      • CLIP-associating protein 1 antibody
      • Cytoplasmic linker associated protein 1 antibody
      • Cytoplasmic linker-associated protein 1 antibody
      • DKFZp686D1968 antibody
      • DKFZp686H2039 antibody
      • FLJ33821 antibody
      • FLJ41222 antibody
      • hOrbit1 antibody
      • KIAA0622 antibody
      • MAST1 antibody
      • MGC131895 antibody
      • mKIAA0622 antibody
      • Multiple asters 1 antibody
      • Multiple asters homolog 1 antibody
      • Protein Orbit homolog 1 antibody
      see all

    Anti-CLASP1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab58105 CLASP1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    References for Anti-CLASP1 antibody (ab58105)

    ab58105 has not yet been referenced specifically in any publications.

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