Overview

  • Product nameAnti-Clathrin heavy chain antibody [2Q2166]
    See all Clathrin heavy chain primary antibodies
  • Description
    Mouse monoclonal [2Q2166] to Clathrin heavy chain
  • SpecificityRecognizes the clathrin heavy chain from a diverse range of species. In nervous tissue it crossreacts with another coated vesicle polypeptide of 190kD which is not present in isolated clathrin triskelions. In some epithelial cells of certain species the antibody may crossreact with a cytokeratin component. It detects coated vesicles from different organs and tissues (e.g. brain, ovary, mammary gland).
  • Tested applicationsSuitable for: IHC-Fr, WBmore details
  • Species reactivity
    Reacts with a wide range of species.
  • Immunogen

    Coated vesicles (clathrin) of bovine brain

Properties

Applications

Our Abpromise guarantee covers the use of ab14401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent dilution.
WB Use at an assay dependent concentration. Predicted molecular weight: 192 kDa.

Target

  • FunctionClathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
  • Sequence similaritiesBelongs to the clathrin heavy chain family.
  • Cellular localizationCytoplasmic vesicle membrane. Membrane > coated pit. Melanosome. Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Alternative names
    • CHC17 antibody
    • Clathrin heavy chain antibody
    • Clathrin heavy chain 1 antibody
    • Clathrin heavy chain 2 antibody
    • Clathrin heavy chain like 1 antibody
    • Clathrin heavy chain on chromosome 17 antibody
    • Clathrin heavy polypeptide antibody
    • CLH 17 antibody
    • CLH 22 antibody
    • CLH-17 antibody
    • CLH1_HUMAN antibody
    • CLH17 antibody
    • CLH22 antibody
    • CLTC antibody
    • CLTCL antibody
    • CLTCL1 antibody
    • CLTCL2 antibody
    • CLTD antibody
    • Hc antibody
    • KIAA0034 antibody
    see all

References for Anti-Clathrin heavy chain antibody [2Q2166] (ab14401)

This product has been referenced in:
  • Sens-Abuázar C  et al. Down-regulation of ANAPC13 and CLTCL1: Early Events in the Progression of Preinvasive Ductal Carcinoma of the Breast. Transl Oncol 5:113-23 (2012). WB, IHC-Fr ; Human . Read more (PubMed: 22496928) »
  • Marx C  et al. ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. Cancer Res 70:3709-17 (2010). WB ; Human . Read more (PubMed: 20406983) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab14401.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"