• Product nameAnti-Claudin 1 antibody
    See all Claudin 1 primary antibodies
  • Description
    Mouse monoclonal to Claudin 1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-212 of Human Claudin 1


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas


Our Abpromise guarantee covers the use of ab56417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 23 kDa.
IHC-P Use a concentration of 3 µg/ml.


  • FunctionClaudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
    (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594).
  • Tissue specificityStrongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
  • Involvement in diseaseIchthyosis-sclerosing cholangitis neonatal syndrome
  • Sequence similaritiesBelongs to the claudin family.
  • Cellular localizationCell junction, tight junction. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Claudin-1 antibody
    • Claudin1 antibody
    • CLD 1 antibody
    • CLD1 antibody
    • CLD1_HUMAN antibody
    • CLDN 1 antibody
    • Cldn1 antibody
    • ILVASC antibody
    • SEMP 1 antibody
    • SEMP1 antibody
    • Senescence associated epithelial membrane protein 1 antibody
    • Senescence associated epithelial membrane protein antibody
    • Senescence-associated epithelial membrane protein antibody
    see all

Anti-Claudin 1 antibody images

  • Claudin 1 antibody (ab56417) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

  • Predicted band size : 23 kDa
    Claudin 1 antibody (ab56417) at 1ug/lane + PRC/PRF/5 cell lysate at 25ug/lane.

References for Anti-Claudin 1 antibody (ab56417)

This product has been referenced in:
  • Koda R  et al. Expression of tight junction protein claudin-1 in human crescentic glomerulonephritis. Int J Nephrol 2014:598670 (2014). IF ; Human . Read more (PubMed: 24868462) »
  • Hou A  et al. Comparison of gene expression profiles in primary and immortalized human pterygium fibroblast cells. Exp Cell Res 319:2781-9 (2013). Read more (PubMed: 24012806) »

See all 3 Publications for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Mouse Tissue sections (mouse pancreas)
Specification mouse pancreas
Fixative Paraformaldehyde
Antigen retrieval step Heat mediated
Permeabilization No
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 20% · Temperature: 16°C

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Submitted Jul 23 2010