Overview

  • Product nameAnti-Claudin 14 antibody
    See all Claudin 14 primary antibodies
  • Description
    Goat polyclonal to Claudin 14
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken
  • Immunogen

    Synthetic peptide:

    SATHSGYRLNDYV

    conjugated to KLH, corresponding to C terminal amino acids 227-239 of Human Claudin 14 (NP_036262.1).

  • Positive control
    • Human pancreas tissue; Human liver lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab115868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 26 kDa.
ELISA 1/128000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionPlays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • Tissue specificityLiver, kidney. Also found in ear.
  • Involvement in diseaseDefects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29) [MIM:605608]. DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similaritiesBelongs to the claudin family.
  • Cellular localizationCell junction > tight junction. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI851731 antibody
    • Claudin 14 antibody
    • Claudin-14 antibody
    • CLD14_HUMAN antibody
    • CLDN 14 antibody
    • CLDN14 antibody
    • DFNB 29 antibody
    • DFNB29 antibody
    • Human CLDN14 gene antibody
    • MGC109472 antibody
    • OTTHUMP00000109046 antibody
    • OTTHUMP00000109049 antibody
    • OTTMUSP00000021531 antibody
    • UNQ777/PRO1571 antibody
    see all

Anti-Claudin 14 antibody images

  • ab115868, at 5 µg/ml, staining Claudin 14 in Formalin-fixed, Paraffin-embedded Human pancreas tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-Claudin 14 antibody (ab115868) at 1 µg/ml + Human liver lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 26 kDa

References for Anti-Claudin 14 antibody (ab115868)

This product has been referenced in:
  • Gao M  et al. The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues. Diagn Pathol 8:205 (2013). Human . Read more (PubMed: 24325792) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"