Anti-Claudin 7 antibody, prediluted (ab27488)

Overview

  • Product nameAnti-Claudin 7 antibody, prediluted
    See all Claudin 7 primary antibodies
  • Description
    Rabbit polyclonal to Claudin 7, prediluted
  • Specificityab27488 recognises claudin 7.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthetic peptide from C-terminus of human claudin 7 protein

  • Positive control
    • Human colon carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab27488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: use neat for 10 min at room temperature. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. In particular, boil tissue sections in 10mM citrate buffer pH 6.0 for 10 min and then cool at room temperature for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays a major role in tight junction-specific obliteration of the intercellular space.
    • Tissue specificityExpressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
    • Sequence similaritiesBelongs to the claudin family.
    • Post-translational
      modifications
      Phosphorylated.
    • Cellular localizationCell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
    • Information by UniProt
    • Database links
    • Alternative names
      • CEPTR L2 antibody
      • CEPTRL 2 antibody
      • CEPTRL2 antibody
      • Claudin 1 antibody
      • Claudin 9 antibody
      • Claudin-7 antibody
      • Claudin1 antibody
      • Claudin7 antibody
      • Claudin9 antibody
      • CLD7_HUMAN antibody
      • CLDN 7 antibody
      • CLDN-7 antibody
      • CLDN7 antibody
      • Clostridium perfringens enterotoxin receptor like 2 antibody
      • CPETR L2 antibody
      • CPETRL 2 antibody
      • CPETRL2 antibody
      • Hs.84359 antibody
      see all

    Anti-Claudin 7 antibody, prediluted images

    • Paraffin embedded formalin fixed human colon carcinoma tissue section stained with anti claudin 7 (ab27488).

    References for Anti-Claudin 7 antibody, prediluted (ab27488)

    ab27488 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"