Overview

  • Product nameAnti-CLCA1 antibody
    See all CLCA1 primary antibodies
  • Description
    Mouse monoclonal to CLCA1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment: ALGGVNAARR RVIPQQSGAL YIPGWIENDE IQWNPPRPEI NKDDVQHKQV CFSRTSSGGS FVASDVPNAP IPDLFPPGQI TDLKAEIHGG SLINLTWTAP , corresponding to amino acids 677-777 of Human CLCA1

Properties

Applications

Our Abpromise guarantee covers the use of ab54662 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
    • Tissue specificityHighly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
    • Sequence similaritiesBelongs to the CLCR family.
      Contains 1 VWFA domain.
    • Post-translational
      modifications
      Glycosylated.
      The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.
    • Cellular localizationSecreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
    • Information by UniProt
    • Database links
    • Alternative names
      • CaCC antibody
      • CaCC-1 antibody
      • CACC1 antibody
      • Calcium dependent chloride channel 1 antibody
      • Calcium-activated chloride channel family member 1 antibody
      • Calcium-activated chloride channel protein 1 antibody
      • Calcium-activated chloride channel regulator 1 antibody
      • Chloride channel calcium activated family member 1 antibody
      • Chloride channel regulator 1 antibody
      • CLCA family member 1 chloride channel regulator antibody
      • CLCA1 antibody
      • CLCA1_HUMAN antibody
      • CLCRG1 antibody
      • GOB5 antibody
      • hCaCC-1 antibody
      • hCLCA1 antibody
      see all

    Anti-CLCA1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab54662 CLCA1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-CLCA1 antibody (ab54662)

    ab54662 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab54662.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"