Overview

  • Product nameAnti-CLCA1 antibody
    See all CLCA1 primary antibodies
  • Description
    Goat polyclonal to CLCA1
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Macaque Monkey, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    PETPSPDETSAPC

    , corresponding to internal sequence amino acids 872-884 of CLCA1 (NP_001276.2)

  • Positive control
    • Human Kidney and Lung lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab77540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notespeptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/64000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 100 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
    • Tissue specificityHighly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
    • Sequence similaritiesBelongs to the CLCR family.
      Contains 1 VWFA domain.
    • Post-translational
      modifications
      Glycosylated.
      The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.
    • Cellular localizationSecreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
    • Information by UniProt
    • Database links
    • Alternative names
      • CaCC antibody
      • CaCC-1 antibody
      • CACC1 antibody
      • Calcium dependent chloride channel 1 antibody
      • Calcium-activated chloride channel family member 1 antibody
      • Calcium-activated chloride channel protein 1 antibody
      • Calcium-activated chloride channel regulator 1 antibody
      • Chloride channel calcium activated family member 1 antibody
      • Chloride channel regulator 1 antibody
      • CLCA family member 1 chloride channel regulator antibody
      • CLCA1 antibody
      • CLCA1_HUMAN antibody
      • CLCRG1 antibody
      • GOB5 antibody
      • hCaCC-1 antibody
      • hCLCA1 antibody
      see all

    Anti-CLCA1 antibody images

    • Anti-CLCA1 antibody (ab77540) at 0.3 µg/ml + Human lung lysate at 35 µg

      Predicted band size : 100 kDa
      Observed band size : 100 kDa

    References for Anti-CLCA1 antibody (ab77540)

    ab77540 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab77540.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"