Overview

  • Product nameAnti-CLCA1 antibody
    See all CLCA1 primary antibodies
  • Description
    Rabbit polyclonal to CLCA1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 542-643 of Human CLCA1 (NP_001276).

  • Positive control
    • A431 whole cell lysate. Sections of gastric CA.

Properties

Applications

Our Abpromise guarantee covers the use of ab96131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 100 kDa.
IHC-P 1/100 - 1/250.

Target

  • FunctionMay be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
  • Tissue specificityHighly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic andhealthy patients. Expressed in the bronchial epithelium, especially in mucus-producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.
  • Sequence similaritiesBelongs to the CLCR family.
    Contains 1 VWFA domain.
  • Post-translational
    modifications
    Glycosylated.
    The 125-kDa product is processed and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37-to 41-kDa proteins.
  • Cellular localizationSecreted > extracellular space. Cell membrane. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
  • Information by UniProt
  • Database links
  • Alternative names
    • CaCC antibody
    • CaCC-1 antibody
    • CACC1 antibody
    • Calcium dependent chloride channel 1 antibody
    • Calcium-activated chloride channel family member 1 antibody
    • Calcium-activated chloride channel protein 1 antibody
    • Calcium-activated chloride channel regulator 1 antibody
    • Chloride channel calcium activated family member 1 antibody
    • Chloride channel regulator 1 antibody
    • CLCA family member 1 chloride channel regulator antibody
    • CLCA1 antibody
    • CLCA1_HUMAN antibody
    • CLCRG1 antibody
    • GOB5 antibody
    • hCaCC-1 antibody
    • hCLCA1 antibody
    see all

Anti-CLCA1 antibody images

  • Anti-CLCA1 antibody (ab96131) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 100 kDa
  • ab96131 at 1/100 dilution staining CLCA1 in paraffin-embedded Gastric CA by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

References for Anti-CLCA1 antibody (ab96131)

ab96131 has not yet been referenced specifically in any publications.

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