Overview

  • Product nameAnti-CLCA2 antibody
    See all CLCA2 primary antibodies
  • Description
    Rabbit polyclonal to CLCA2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Horse, Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within the internal sequence amino acids 674-723 (RYFFSFAANG RYSLKVHVNH SPSISTPAHS IPGSHAMYVP GYTANGNIQM) of Human CLCA2 (NP_006527.1).

  • Positive control
    • THP-1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab108101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 104 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionPlay a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
  • Tissue specificityExpressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules.
  • Sequence similaritiesBelongs to the CLCR family.
    Contains 1 VWFA domain.
  • Post-translational
    modifications
    The 141 kDa mature form is shedded, producing a 109 kDa form and a 35 kDa form.
    N-glycosylated.
  • Cellular localizationCell membrane. Basal cell membrane. Cell junction and Secreted. Remains associated to the 35 kDa form until an unidentified event triggers the release.
  • Information by UniProt
  • Database links
  • Alternative names
    • 35 kDa form antibody
    • CaCC-3 antibody
    • CaCC3 antibody
    • Calcium-activated chloride channel family member 2 antibody
    • Calcium-activated chloride channel protein 3 antibody
    • Calcium-activated chloride channel regulator 2 antibody
    • Calcium-activated chloride channel-2 antibody
    • Chloride channel, calcium activated, family member 2 antibody
    • Clca2 antibody
    • CLCA2_HUMAN antibody
    • hCaCC-3 antibody
    • hCLCA2 antibody
    see all

Anti-CLCA2 antibody images

  • Anti-CLCA2 antibody (ab108101) at 1 µg/ml + THP-1 cell lysate at 10 µg

    Predicted band size : 104 kDa

References for Anti-CLCA2 antibody (ab108101)

ab108101 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"