• Product nameAnti-CLCA2 antibody
    See all CLCA2 primary antibodies
  • Description
    Mouse monoclonal to CLCA2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 300-401 of Human CLCA2



Our Abpromise guarantee covers the use of ab56634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlay a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
    • Tissue specificityExpressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules.
    • Sequence similaritiesBelongs to the CLCR family.
      Contains 1 VWFA domain.
    • Post-translational
      The 141 kDa mature form is shedded, producing a 109 kDa form and a 35 kDa form.
    • Cellular localizationCell membrane. Basal cell membrane. Cell junction and Secreted. Remains associated to the 35 kDa form until an unidentified event triggers the release.
    • Information by UniProt
    • Database links
    • Alternative names
      • 35 kDa form antibody
      • CaCC-3 antibody
      • CaCC3 antibody
      • Calcium-activated chloride channel family member 2 antibody
      • Calcium-activated chloride channel protein 3 antibody
      • Calcium-activated chloride channel regulator 2 antibody
      • Calcium-activated chloride channel-2 antibody
      • Chloride channel, calcium activated, family member 2 antibody
      • Clca2 antibody
      • CLCA2_HUMAN antibody
      • hCaCC-3 antibody
      • hCLCA2 antibody
      see all

    Anti-CLCA2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56634 CLCA2 antibody at 1ug/ml. Predicted band size of immunogen is 80 kDa

    References for Anti-CLCA2 antibody (ab56634)

    ab56634 has not yet been referenced specifically in any publications.

    Product Wall

    Application Western blot
    Sample Human Cell lysate - whole cell (NPC cell lines)
    Loading amount 105 µg
    Specification NPC cell lines
    Treatment Both boil and non-boil (95 degree celcius, 10mins)
    Gel Running Conditions Reduced Denaturing (Gel 10%)
    Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

    Abcam user community

    Verified customer

    Submitted Oct 26 2009