Anti-CLCA4 antibody (ab121524)
Key features and details
- Rabbit polyclonal to CLCA4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CLCA4 antibody
See all CLCA4 primary antibodies -
Description
Rabbit polyclonal to CLCA4 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence: WVGMVHFDST ATIVNKLIQI KSSDERNTLM AGLPTYPLGG TSICSGIKYA FQVIGELHSQ LDGSEVLLLT DGEDNTASSC IDEV, corresponding to amino acids 56-139 of Human CLCA4.
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Positive control
- Human duodenum.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab121524 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
May be involved in mediating calcium-activated chloride conductance. -
Tissue specificity
Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp. -
Sequence similarities
Belongs to the CLCR family.
Contains 1 VWFA domain. -
Post-translational
modificationsProcessed at a monobasic residue to yield a larger N-terminal and a smaller C-terminal cleavage products of 90 to 110 and 30 to 35 kDa, respectively. -
Cellular localization
Cell membrane. Apical cell membrane. Secreted. The C-terminus 30 kDa form is anchored to the membrane (By similarity). The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. - Information by UniProt
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Database links
- Entrez Gene: 22802 Human
- SwissProt: Q14CN2 Human
- Unigene: 567422 Human
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Alternative names
- 30 kDa form antibody
- CaCC-2 antibody
- Calcium-activated chloride channel family member 4 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab121524 has not yet been referenced specifically in any publications.