FunctionChloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
Tissue specificityTestis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.
Sequence similaritiesBelongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. Contains 2 CBS domains.
Post-translational modificationsN-glycosylated on several asparagine residues.
Cellular localizationEndosome membrane. Detected in detergent-resistant lipid rafts.