Overview

  • Product nameAnti-CLCNKB antibody
    See all CLCNKB primary antibodies
  • Description
    Rabbit polyclonal to CLCNKB
  • Tested applicationsSuitable for: IHC-P, WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    Synthetic peptide derived from the C terminal domain of Mouse CLCNKB

Properties

Applications

Our Abpromise guarantee covers the use of ab66460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 75 kDa.
IHC-Fr Use at an assay dependent concentration.

Target

  • FunctionVoltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
  • Tissue specificityExpressed predominantly in the kidney.
  • Involvement in diseaseDefects in CLCNKB are the cause of Bartter syndrome type 3 (BS3) [MIM:607364]; also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels.
    Defects in CLCNKB are a cause of Bartter syndrome type 4B (BS4B) [MIM:613090]. A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness.
  • Sequence similaritiesBelongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
    Contains 2 CBS domains.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bartter syndrome type 3 antibody
    • Chloride channel Kb antibody
    • Chloride channel kidney B antibody
    • Chloride channel protein ClC-Kb antibody
    • Chloride channel voltage sensitive Kb antibody
    • ClC K2 antibody
    • ClC-K2 antibody
    • ClCK2 antibody
    • CLCKB antibody
    • CLCKB_HUMAN antibody
    • CLCNKB antibody
    • hClC Kb antibody
    • hClCKb antibody
    • MGC24087 antibody
    • OTTHUMP00000011120 antibody
    • OTTHUMP00000011121 antibody
    • RP11 5P18.8 antibody
    see all

References for Anti-CLCNKB antibody (ab66460)

ab66460 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"