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Anti-Cleaved alpha-fodrin (Asp1185) antibody [EPR3830-17]
Rabbit monoclonal [EPR3830-17] to Cleaved alpha-fodrin (Asp1185)
Only detects the large fragment of Alpha Fodrin resulting from cleavage at aspartic acid 1185.
IP more details Unsuitable for:
Flow Cyt,ICC or IHC-P
corresponding to Human Cleaved alpha-fodrin (Asp1185) aa 1150-1250.
HeLa + Camptothecin cell lysate, HeLa cell lysate, Jurkat + Staurosporine cell lysate, Jurkat cell lysate
This product is a recombinant rabbit monoclonal antibody.
Produced using Abcam’s RabMAb
® technology. RabMAb ® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10000 - 1/50000. Predicted molecular weight: 285 kDa.
1/10 - 1/100.
Is unsuitable for Flow Cyt,ICC or IHC-P.
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Involvement in disease
Epileptic encephalopathy, early infantile, 5
Belongs to the spectrin family.
Contains 3 EF-hand domains. Contains 1 SH3 domain. Contains 23 spectrin repeats.
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Information by UniProt
Alpha-II spectrin antibody
Fodrin alpha chain antibody
non-erythrocytic 1 antibody
Anti-Cleaved alpha-fodrin (Asp1185) antibody [EPR3830-17] images
Western blot - Anti-Cleaved alpha-fodrin (Asp1185) antibody [EPR3830-17] (ab92373)
All lanes :
Anti-Cleaved alpha-fodrin (Asp1185) antibody [EPR3830-17] (ab92373)
Lane 1 :
HeLa + Camptothecin cell lysate
Lane 2 :
HeLa cell lysate
Lane 3 :
Jurkat + Staurosporine cell lysate
Lane 4 :
Jurkat cell lysate
Lysates/proteins at 10 µg per lane.
HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size :
Observed band size :
150 kDa (
why is the actual band size different from the predicted?
References for Anti-Cleaved alpha-fodrin (Asp1185) antibody [EPR3830-17] (ab92373)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"