Overview

  • Product nameAnti-CLEC12A antibody
    See all CLEC12A primary antibodies
  • Description
    Rabbit polyclonal to CLEC12A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, between amino acids 185-214 from the Central region of Human CLEC12A (NP_612210.4, NP_963917.2).

  • Positive control
    • ZR-75-1 cell line lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab107494 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab107494 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 31 kDa.

Target

  • FunctionCell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • Tissue specificityDetected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
  • Sequence similaritiesContains 1 C-type lectin domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Highly N-glycosylated. Glycosylation varies between cell types.
  • Cellular localizationCell membrane. Ligand binding leads to internalization.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-type lectin domain family 12 member A antibody
    • C-type lectin-like molecule 1 antibody
    • CL12A_HUMAN antibody
    • CLEC12A antibody
    • CLL-1 antibody
    • DCAL-2 antibody
    • Dendritic cell-associated lectin 2 antibody
    • MICL antibody
    • Myeloid inhibitory C-type lectin-like receptor antibody
    see all

Anti-CLEC12A antibody images

  • Anti-CLEC12A antibody (ab107494) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

    Predicted band size : 31 kDa

References for Anti-CLEC12A antibody (ab107494)

ab107494 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"