Overview

  • Product name
  • Description
    Rabbit polyclonal to CLEC12A
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, between amino acids 185-214 from the Central region of Human CLEC12A (NP_612210.4, NP_963917.2).

  • Positive control
    • ZR-75-1 cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab107494 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab107494 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 31 kDa.

Target

  • Function
    Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • Tissue specificity
    Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
  • Sequence similarities
    Contains 1 C-type lectin domain.
  • Domain
    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Highly N-glycosylated. Glycosylation varies between cell types.
  • Cellular localization
    Cell membrane. Ligand binding leads to internalization.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-type lectin domain family 12 member A antibody
    • C-type lectin-like molecule 1 antibody
    • CL12A_HUMAN antibody
    • CLEC12A antibody
    • CLL-1 antibody
    • DCAL-2 antibody
    • Dendritic cell-associated lectin 2 antibody
    • MICL antibody
    • Myeloid inhibitory C-type lectin-like receptor antibody
    see all

Images

  • Anti-CLEC12A antibody (ab107494) at 1/100 dilution + ZR-75-1 cell line lysate at 35 µg

    Predicted band size : 31 kDa

References

ab107494 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab107494.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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