Overview

  • Product nameAnti-CLEC1B antibody [17D9]
    See all CLEC1B primary antibodies
  • Description
    Rat monoclonal [17D9] to CLEC1B
  • Tested applicationsSuitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation (Mouse): RBL-2H3 cells stably expressing HA-tagged mouse CLEC1B.

Properties

Applications

Our Abpromise guarantee covers the use of ab90542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 20 kDa.
Flow Cyt Use at an assay dependent concentration. ab18536-Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

Target

  • FunctionActs as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
  • Tissue specificityExpressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
  • Sequence similaritiesContains 1 C-type lectin domain.
  • Post-translational
    modifications
    Glycosylated.
    Phosphorylated on tyrosine residue in response to rhodocytin binding.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1810061I13Rik antibody
    • C type lectin domain family 1 member B antibody
    • C type lectin like receptor 2 antibody
    • C-type lectin domain family 1 member B antibody
    • C-type lectin domain family 1, member B antibody
    • C-type lectin-like receptor 2 antibody
    • C-type lectin-like receptor-2 antibody
    • CLC1B_HUMAN antibody
    • CLEC 2 antibody
    • CLEC 2B antibody
    • CLEC-2 antibody
    • CLEC1B antibody
    • CLEC2 antibody
    • CLEC2B antibody
    • PRO1384 antibody
    • QDED721 antibody
    see all

Anti-CLEC1B antibody [17D9] images

References for Anti-CLEC1B antibody [17D9] (ab90542)

This product has been referenced in:
  • Kerrigan AM  et al. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 182:4150-7 (2009). Read more (PubMed: 19299712) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"