Anti-CLEC-2 antibody (ab81983)
Key features and details
- Goat polyclonal to CLEC-2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CLEC-2 antibody
See all CLEC-2 primary antibodies -
Description
Goat polyclonal to CLEC-2 -
Host species
Goat -
Specificity
ab81983 is expected to recognize both reported isoforms (NP_001092901.1; NP_057593.3) -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human CLEC-2 aa 95-108 (internal sequence). (NP_001092901.1; NP_057593.3)
Sequence:KGHKCSPCDTNWRY
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Positive control
- Human bone marrow and human kidney lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris buffered saline -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab81983 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 27 kDa.
1 hour primary incubation is recommended for this product. |
Notes |
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WB
Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 27 kDa. 1 hour primary incubation is recommended for this product. |
Target
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Function
Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. -
Tissue specificity
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. -
Sequence similarities
Contains 1 C-type lectin domain. -
Post-translational
modificationsGlycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 51266 Human
- Omim: 606783 Human
- SwissProt: Q9P126 Human
- Unigene: 409794 Human
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Alternative names
- 1810061I13Rik antibody
- C type lectin domain family 1 member B antibody
- C type lectin like receptor 2 antibody
see all
Images
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Anti-CLEC-2 antibody (ab81983) at 1 µg/ml + human kidney lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 27 kDa
Observed band size: 30 kDa why is the actual band size different from the predicted?
Exposure time: 1 hour
Datasheets and documents
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Datasheet download
References (0)
ab81983 has not yet been referenced specifically in any publications.