Anti-CLECSF6 antibody [MM0237- 5P20] (ab89188)

Overview

  • Product nameAnti-CLECSF6 antibody [MM0237- 5P20]
    See all CLECSF6 primary antibodies
  • Description
    Mouse monoclonal [MM0237- 5P20] to CLECSF6
  • Tested applicationsSuitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    human recombinant CLECSF6 extracellular domain.

Properties

Applications

Our Abpromise guarantee covers the use of ab89188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 28 kDa.
Flow Cyt 1/50 - 1/200. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionMay be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
  • Tissue specificityExpressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).
  • Sequence similaritiesContains 1 C-type lectin domain.
  • DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6 antibody
    • C type lectin antibody
    • C type lectin DDB27 antibody
    • C type lectin superfamily 6 antibody
    • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 antibody
    • C-type lectin superfamily member 6 antibody
    • C-type lectin DDB27 antibody
    • C-type lectin domain family 4 member A antibody
    • C-type lectin domain family 4, member A antibody
    • C-type lectin domain family 4, member a2 antibody
    • C-type lectin superfamily member 6 antibody
    • CLC4A_HUMAN antibody
    • Clec4a antibody
    • Clec4a2 antibody
    • CLECSF6 antibody
    • DCIR antibody
    • Dcir1 antibody
    • DDB27 antibody
    • Dendritic cell immunoreceptor antibody
    • HDCGC13P antibody
    • Lectin like immunoreceptor antibody
    • Lectin, C-type, superfamily member 6 antibody
    • Lectin-like immunoreceptor antibody
    • LLIR antibody
    see all

References for Anti-CLECSF6 antibody [MM0237- 5P20] (ab89188)

ab89188 has not yet been referenced specifically in any publications.

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