Overview

  • Product nameAnti-CLIC2 antibody
    See all CLIC2 primary antibodies
  • Description
    Mouse polyclonal to CLIC2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human CLIC2 protein (NP_001280.3)

  • Positive control
    • Human spleen tissue lysate and CLIC2 transfected 293T cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab89916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).

Target

  • FunctionCan insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
  • Tissue specificityDetected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle.
  • Sequence similaritiesBelongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • DomainMembers of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Cellular localizationCytoplasm. Membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • Chloride intracellular channel 2 antibody
    • Chloride intracellular channel protein 2 antibody
    • CLIC 2b antibody
    • CLIC2 antibody
    • CLIC2_HUMAN antibody
    • CLIC2b antibody
    • MRXS32 antibody
    • OTTHUMP00000196471 antibody
    • XAP 121 antibody
    • XAP121 antibody
    see all

Anti-CLIC2 antibody images

  • Anti-CLIC2 antibody (ab89916) at 1 µg/ml + Human spleen tissue lysate at 50 µg

    Predicted band size : 28 kDa
    Observed band size : 28 kDa
    Additional bands at : 26 kDa,35 kDa. We are unsure as to the identity of these extra bands.
  • All lanes : Anti-CLIC2 antibody (ab89916) at 1 µg/ml

    Lane 1 : CLIC2 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 28 kDa
    Observed band size : 28 kDa

References for Anti-CLIC2 antibody (ab89916)

ab89916 has not yet been referenced specifically in any publications.

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