Recombinant
RabMAb

Anti-CLIC2 antibody [EPR6495] (ab126727)

Overview

  • Product name
    Anti-CLIC2 antibody [EPR6495]
    See all CLIC2 primary antibodies
  • Description
    Rabbit monoclonal [EPR6495] to CLIC2
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human CLIC2 (UniProt O15247).

  • Positive control
    • Human fetal liver, Human heart, and Human testis lysates.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab126727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function
      Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.
    • Tissue specificity
      Detected in adult brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and adult skeletal muscle.
    • Sequence similarities
      Belongs to the chloride channel CLIC family.
      Contains 1 GST C-terminal domain.
    • Domain
      Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
    • Cellular localization
      Cytoplasm. Membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • Chloride intracellular channel 2 antibody
      • Chloride intracellular channel protein 2 antibody
      • CLIC 2b antibody
      • CLIC2 antibody
      • CLIC2_HUMAN antibody
      • CLIC2b antibody
      • MRXS32 antibody
      • OTTHUMP00000196471 antibody
      • XAP 121 antibody
      • XAP121 antibody
      see all

    Images

    • All lanes : Anti-CLIC2 antibody [EPR6495] (ab126727) at 1/1000 dilution

      Lane 1 : Human fetal liver lysate
      Lane 2 : Human heart lysate
      Lane 3 : Human testis lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 28 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab126727 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab126727.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up