Overview

  • Product nameAnti-CLLD8/SETDB2 antibody
    See all CLLD8/SETDB2 primary antibodies
  • Description
    Mouse monoclonal to CLLD8/SETDB2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 451-551 of human CLLD8/SETDB2 (NP_114121) with a proprietary tag.

  • Positive control
    • The immunogen; A-431 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab89173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 82 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionHistone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
  • Tissue specificityUbiquitous. Highest expression in heart, testis and ovary.
  • Sequence similaritiesBelongs to the histone-lysine methyltransferase family.
    Contains 1 MBD (methyl-CpG-binding) domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • Cellular localizationNucleus. Chromosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • C13orf4 antibody
    • Chromosome 13 open reading frame 4 antibody
    • Chronic lymphocytic leukemia deletion region 8 antibody
    • Chronic lymphocytic leukemia deletion region gene 8 antibody
    • Chronic lymphocytic leukemia deletion region gene 8 protein antibody
    • Clld8 antibody
    • CLLL8 antibody
    • Gm293 antibody
    • H3-K9-HMTase antibody
    • Histone H3-K9 methyltransferase antibody
    • Histone-lysine N-methyltransferase SETDB2 antibody
    • KMT1F antibody
    • Lysine N-methyltransferase 1F antibody
    • Probable histone-lysine N-methyltransferase H3 lysine-9 specific antibody
    • SEB2 antibody
    • SET domain bifurcated 2 antibody
    • SET domain protein, bifurcated, 2 antibody
    • SETB2_HUMAN antibody
    • Setdb2 antibody
    see all

Anti-CLLD8/SETDB2 antibody images

  • Anti-CLLD8/SETDB2 antibody (ab89173) at 5 µg/ml + tagged, recombinant human CLLD8/SETDB2 protein fragment (the immunogen) at 0.2 µg
    Developed using the ECL technique

    Predicted band size : 82 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-CLLD8/SETDB2 antibody (ab89173) at 5 µg/ml + A-431 cell lysate at 50 µg
    Developed using the ECL technique

    Predicted band size : 82 kDa
    Observed band size : 80 kDa (why is the actual band size different from the predicted?)

References for Anti-CLLD8/SETDB2 antibody (ab89173)

ab89173 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"