Anti-CLNS1A/CLCI antibody [2187C2a] (ab53667)
Key features and details
- Mouse monoclonal [2187C2a] to CLNS1A/CLCI
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-CLNS1A/CLCI antibody [2187C2a]
See all CLNS1A/CLCI primary antibodies -
Description
Mouse monoclonal [2187C2a] to CLNS1A/CLCI -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to CLNS1A/CLCI (C terminal).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.0225% Potassium chloride, 0.0204% Monobasic dihydrogen potassium phosphate, 0.1136% Dibasic monohydrogen sodium phosphate, 1% BSA, 0.03% Potassium phosphate, 0.812% Sodium chloride, 0.1312% Sodium phosphate -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
ab53667 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum. -
Clonality
Monoclonal -
Clone number
2187C2a -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab53667 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 26 kDa.
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Notes |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 26 kDa. |
Target
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Function
The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. -
Sequence similarities
Belongs to the pICln family. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. A small fraction is also associated with the cytoskeleton. - Information by UniProt
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Database links
- Entrez Gene: 1207 Human
- Omim: 602158 Human
- SwissProt: P54105 Human
- Unigene: 430733 Human
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Alternative names
- Chloride channel antibody
- Chloride channel nucleotide sensitive 1A antibody
- Chloride channel regulatory protein antibody
see all
Images
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Anti-CLNS1A/CLCI antibody [2187C2a] (ab53667) + Immunized recombinant protein
Predicted band size: 26 kDa
Observed band size: 39 kDa why is the actual band size different from the predicted?
Datasheets and documents
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Datasheet download
References (0)
ab53667 has not yet been referenced specifically in any publications.