Anti-Clostridium botulinum A Toxoid antibody [230F9] (ab40786)

Overview

  • Product nameAnti-Clostridium botulinum A Toxoid antibody [230F9]
    See all Clostridium botulinum A Toxoid primary antibodies
  • Description
    Mouse monoclonal [230F9] to Clostridium botulinum A Toxoid
  • SpecificityBoTox-A (1280-1292) 100%; BoTox-A 100% Does not cross react with BoTox-B, BoTox-C, BoTox-E or BoTox-F (1272-1280)
  • Tested applicationsSuitable for: ICC/IF, Inhibition Assaymore details
  • Immunogen

    Synthetic peptide analogue of the carboxyl terminal region of BoTox-A.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: Tissue culture supernatant
  • PurityTissue culture supernatant
  • Purification notesSterile filtered culture supernatant.
  • ClonalityMonoclonal
  • Clone number230F9
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab40786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent dilution.
Inhibition Assay Use at an assay dependent dilution. Inhibits BoTox-A binding to Neuro2A cells treated with GT1b ganglioside which can be eliminated by prior incubation with synthetic peptide immunogen.

Target

  • RelevanceClostridium botulinum neurotoxins are zinc-dependent proteases that block the release of acetylcholine from peripheral cholinergic nerve endings by targeting specific membrane proteins including synaptosomal-associated proteins (SNAP), vesicle-associated membrane proteins (VAMP), and syntaxins. Neurotoxin A is characteristically associated with human botulism and known to target and hydrolyse the 197-Gln-|-Arg-198 bond of SNAP-25.
  • Alternative names
    • Atx antibody
    • BotA antibody
    • BOTOX antibody
    • Botulinum neurotoxin type A antibody
    • Botulism A toxoid antibody
    see all

References for Anti-Clostridium botulinum A Toxoid antibody [230F9] (ab40786)

ab40786 has not yet been referenced specifically in any publications.

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The immunogen of antibody ab40786 is a "synthetic peptide analogue of the carboxyl terminal region of BoTox-A", http://www.uniprot.org/uniprot/P10845.

We have not tested this antibody in WB, if y...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"