Overview

  • Product name
    Anti-CMIP antibody - C-terminal
    See all CMIP primary antibodies
  • Description
    Rabbit polyclonal to CMIP - C-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C-terminal amino acids 701-780 of Human CMIP (NP_085132.1).

  • Positive control
    • HepG2 cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab156385 is purified through a Protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab156385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 86 kDa.

Target

  • Function
    Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
  • Tissue specificity
    Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.
  • Sequence similarities
    Contains 4 LRR (leucine-rich) repeats.
    Contains 1 PH domain.
  • Developmental stage
    Expressed in fetal liver.
  • Cellular localization
    Nucleus. Cytoplasm. Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-Maf-inducing protein antibody
    • c-Mip antibody
    • cmip antibody
    • CMIP_HUMAN antibody
    • KIAA1694 antibody
    • Tc-Mip antibody
    • TCMIP antibody
    • Truncated c-Maf-inducing protein antibody
    see all

Images

  • Anti-CMIP antibody - C-terminal (ab156385) at 1/100 dilution + HepG2 cell line lysate at 35 µg

    Predicted band size : 86 kDa

References

ab156385 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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