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Mouse polyclonal to CMPK2
Recombinant fragment (GST-tag) corresponding to Human CMPK2 aa 151-250. (NP_997198).
Jurkat cell lysate; recombinant Human CMPK2 protein (immunogen).
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/2500. Predicted molecular weight: 49 kDa.
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.
Among all investigated tumors, leukemia cells show the most abundant expression.
Belongs to the thymidylate kinase family.
Information by UniProt
has not yet been referenced specifically in any publications.
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