Overview

  • Product name
  • Description
    Rabbit polyclonal to CNBP
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 92-119 of Human CNBP (NP_001120665.1).

  • Positive control
    • NCI-H292 cell line lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab156420 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab156420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 19 kDa.

Target

  • Function
    Single stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
  • Tissue specificity
    Present in all tissues examined.
  • Involvement in disease
    Defects in CNBP are the cause of dystrophia myotonica type 2 (DM2) [MIM:602668]; also known as proximal myotonic myopathy (PROMM). A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases. Note=The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene.
  • Sequence similarities
    Contains 7 CCHC-type zinc fingers.
  • Cellular localization
    Cytoplasm. Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • CCHC type zinc finger nucleic acid binding protein antibody
    • Cellular nucleic acid binding protein antibody
    • Cellular nucleic acid-binding protein antibody
    • CNBP antibody
    • CNBP_HUMAN antibody
    • CNBP1 antibody
    • DM2 antibody
    • Erythroid differentiation related antibody
    • PROMM antibody
    • Proximal myotonic myopathy nucleic acid binding protein antibody
    • RNF163 antibody
    • Sterol regulatory element binding protein antibody
    • ZCCHC22 antibody
    • Zinc finger protein 273 antibody
    • Zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) antibody
    • Zinc finger protein 9 antibody
    • ZNF9 antibody
    see all

Images

  • Anti-CNBP antibody (ab156420) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size: 19 kDa

References

This product has been referenced in:
  • Phillips SL  et al. Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication. MBio 7:e01865-15 (2016). Read more (PubMed: 26733069) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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