• Product name
  • Description
    Rabbit polyclonal to CNG3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human CNG3.

    (Peptide available as ab109061.)

  • Positive control
    • This antibody gave a positive signal in Mouse Retina Tissue Lysate.



Our Abpromise guarantee covers the use of ab97500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 79 kDa (predicted molecular weight: 79 kDa).


  • Function
    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
  • Tissue specificity
    Prominently expressed in retina.
  • Involvement in disease
    Defects in CNGA3 are the cause of achromatopsia type 2 (ACHM2) [MIM:216900]; also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night.
  • Sequence similarities
    Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily.
    Contains 1 cyclic nucleotide-binding domain.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • ACHM2 antibody
    • CCNC1 antibody
    • CCNCa antibody
    • CCNCalpha antibody
    • CNCG3 antibody
    • CNG 3 antibody
    • CNG channel alpha 3 antibody
    • CNG channel alpha-3 antibody
    • CNG-3 antibody
    • CNG3 antibody
    • CNGA3 antibody
    • Cnga3 cyclic nucleotide gated channel alpha 3 antibody
    • CNGA3_HUMAN antibody
    • Cone photoreceptor cGMP gated channel antibody
    • Cone photoreceptor cGMP gated channel alpha subunit antibody
    • Cone photoreceptor cGMP gated channel subunit alpha antibody
    • Cone photoreceptor cGMP-gated channel subunit alpha antibody
    • Cyclic nucleotide gated cation channel alpha 3 antibody
    • Cyclic nucleotide gated channel alpha 3 antibody
    • Cyclic nucleotide gated channel olfactory 3 antibody
    • Cyclic nucleotide gated channel rod photoreceptor subunit alpha antibody
    • Cyclic nucleotide-gated cation channel alpha-3 antibody
    • Cyclic nucleotide-gated channel alpha-3 antibody
    • OTTHUMP00000161120 antibody
    see all


  • Anti-CNG3 antibody (ab97500) at 1 µg/ml + Mouse Retina Tissue Lysate at 10 µg

    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 79 kDa
    Observed band size : 79 kDa
    Additional bands at : 46 kDa,55 kDa,70 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 2 minutes


ab97500 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab97500.
Please use the links above to contact us or submit feedback about this product.


Sign up