• Product nameAnti-CNGB3 antibody
  • Description
    Rabbit polyclonal to CNGB3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 33-63 of Human CNGB3 (NP_061971.3).

  • Positive control
    • MDA-MB435 cell line lysates



Our Abpromise guarantee covers the use of ab113056 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 92 kDa.


  • FunctionVisual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
  • Tissue specificityExpressed specifically in the retina.
  • Involvement in diseaseDefects in CNGB3 are the cause of Stargardt disease type 1 (STGD1) [MIM:248200]. STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal recessive.
    Defects in CNGB3 are the cause of achromatopsia type 3 (ACHM3) [MIM:262300]; also known as Pingelapese blindness. ACHM3 is a congenital complete achromatopsia and is distinct from total colorblindness mainly because of the consistent concurrence of severe myopia.
  • Sequence similaritiesBelongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily.
    Contains 1 cyclic nucleotide-binding domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACHM1 antibody
    • ACHM3 antibody
    • Achromatopsia (rod monochromacy) 3 antibody
    • CNG channel beta-3 antibody
    • CNGB3 antibody
    • CNGB3_HUMAN antibody
    • Cone photoreceptor cGMP-gated cation channel beta-subunit antibody
    • Cone photoreceptor cGMP-gated channel subunit beta antibody
    • Cyclic nucleotide gated channel beta 3 antibody
    • Cyclic nucleotide-gated cation channel beta-3 antibody
    • Cyclic nucleotide-gated cation channel modulatory subunit antibody
    • Cyclic nucleotide-gated channel beta-3 antibody
    • RMCH antibody
    • RMCH1 antibody
    see all

Anti-CNGB3 antibody images

  • Anti-CNGB3 antibody (ab113056) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size : 92 kDa

References for Anti-CNGB3 antibody (ab113056)

ab113056 has not yet been referenced specifically in any publications.

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