Involved in the selective transport and maturation of TGF-alpha family proteins.
Highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes and bone marrow. Lower expression found in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus and fetal liver.
Belongs to the cornichon family.
Endoplasmic reticulum membrane. Golgi apparatus membrane. Located primarily in the ER; may cycle between the ER and the Golgi apparatus.