FunctionProbable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.
Tissue specificityWidely expressed. Highly expressed in heart.
Involvement in diseaseDefects in CNNM4 are the cause of Jalili syndrome (JALIS) [MIM:217080]. A syndrome characterized by the association of cone-rod dystrophy and amelogenesis imperfecta.
Sequence similaritiesBelongs to the ACDP family. Contains 2 CBS domains. Contains 1 DUF21 domain.