Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function.
Widely expressed. Highly expressed in heart.
Involvement in disease
Defects in CNNM4 are the cause of Jalili syndrome (JALIS) [MIM:217080]. A syndrome characterized by the association of cone-rod dystrophy and amelogenesis imperfecta.
Belongs to the ACDP family. Contains 2 CBS domains. Contains 1 DUF21 domain.
Ancient conserved domain-containing protein 4 antibody
Cyclin and CBS domain divalent metal cation transport mediator 4 antibody
Cyclin M4 antibody
Metal transporter CNNM4 antibody
Western blot - Anti-CNNM4 antibody (ab191207)
All lanes : Anti-CNNM4 antibody (ab191207) at 0.4 µg/ml
Lane 1 : HeLa whole cell lysate prepared using RIPA Lane 2 : 293T whole cell lysate prepared using RIPA Lane 3 : Jurkat whole cell lysate prepared using RIPA Lane 4 : mouse TMCM-1 whole cell lysate prepared using NETN Lane 5 : mouse NIH 3T3 whole cell lysate prepared using NETN
Immunoprecipitation analysis of HeLa whole cell lysate prepared using RIPA lysis buffer (1.0 mg per IP reaction; 20% of IP loaded) using ab191207 used at 6 µg per reaction lane 1. Lane 2 shows control IgG. For blotting ab191207 was used at 1 µg/ml. Chemiluminescence with an exposure time of 30 seconds.