Overview

  • Product name
  • Description
    Goat polyclonal to CNTN4
  • Specificity
    This antibody is expected to recognize both reported isoforms (NP_001103219.1; NP_766592.2).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Dog, Human
  • Immunogen

    Synthetic peptide:

    RRADGKPIARK

    by a Cysteine residue linker, corresponding to internal sequence amino acids 260-270 of Mouse CNTN4 (NP_001103219.1; NP_766592.2).

  • Positive control
    • Mouse olfactory bulb and cerebral cortex lysate; Lysate of HEK293 overexpressing Mouse CNTN4.

Properties

Applications

Our Abpromise guarantee covers the use of ab156933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 150 kDa (predicted molecular weight: 113 kDa).

Target

  • Function
    Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
  • Tissue specificity
    Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.
  • Involvement in disease
    A chromosomal aberration involving CNTN4 has been found in a boy with characteristic physical features of 3p deletion syndrome (3PDS). Translocation t(3;10)(p26;q26). 3PDS is a rare contiguous gene disorder involving the loss of the telomeric portion of the short arm of chromosome 3 and characterized by developmental delay, growth retardation, and dysmorphic features.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. Contactin family.
    Contains 4 fibronectin type-III domains.
    Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Cellular localization
    Cell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • AXCAM antibody
    • Axonal associated cell adhesion molecule antibody
    • BIG 2 antibody
    • BIG-2 antibody
    • Brain derived immunoglobulin superfamily protein 2 antibody
    • Brain-derived immunoglobulin superfamily protein 2 antibody
    • Cntn4 antibody
    • CNTN4_HUMAN antibody
    • CNTN4A antibody
    • contactin 4 antibody
    • Contactin-4 antibody
    • Neural cell adhesion protein BIG 2 antibody
    • SCA16 antibody
    see all

Images

  • All lanes : Anti-CNTN4 antibody (ab156933) at 0.5 µg/ml

    Lane 1 : KO Mouse olfactory bulb
    Lane 2 : KO Mouse cerebral cortex
    Lane 3 : Wild type Mouse olfactory bulb
    Lane 4 : Wild type Mouse cerebral cortex
    Lane 5 : HEK293 overexpressing Mouse CNTN4 lysate

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique

    Predicted band size : 113 kDa
    Observed band size : 150 kDa (why is the actual band size different from the predicted?)

    Data obtained from Gerrald Lodewijk and Peter Burbach, Rudolf Magnus Institute, Utrecht, Netherlands.

References

ab156933 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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