Overview

  • Product nameAnti-COCH antibody
    See all COCH primary antibodies
  • Description
    Mouse polyclonal to COCH
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-494 of Human COCH

  • Positive control
    • COCH transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab72581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 54 kDa.

Target

  • FunctionPlays a role in the control of cell shape and motility in the trabecular meshwork.
  • Tissue specificityExpressed in inner ear structures; the cochlea and the vestibule.
  • Involvement in diseaseDefects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9) [MIM:601369]. DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers.
  • Sequence similaritiesContains 1 LCCL domain.
    Contains 2 VWFA domains.
  • Post-translational
    modifications
    N-glycosylated.
    A 50 kDa form is created by proteolytic cleavage.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Coagulation factor C homolog, cochlin (Limulus polyphemus) antibody
    • COCH antibody
    • COCH-5B2 antibody
    • COCH_HUMAN antibody
    • COCH5B2 antibody
    • Cochlin antibody
    • DFNA9 antibody
    see all

Anti-COCH antibody images

  • All lanes : Anti-COCH antibody (ab72581) at 1/500 dilution

    Lane 1 : COCH transfected 293T cell lysate
    Lane 2 : non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 54 kDa
    Observed band size : 54 kDa

References for Anti-COCH antibody (ab72581)

ab72581 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"