Overview

  • Product name
  • Description
    Mouse polyclonal to CoCoA
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length protei, corresponding to amino acids 1-691 of Human CoCoA (NP_065949.1).

  • Positive control
    • Rat brain tissue lysate; CoCoA transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab167237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 77 kDa.

Target

  • Relevance
    Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1 mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
  • Cellular localization
    Cytoplasm. Nucleus. Note: shuttles between nucleus and cytoplasm.
  • Database links
  • Alternative names
    • Calcium binding and coiled coil domain 1 antibody
    • CALCOCO1 antibody
    • Calphoglin antibody
    • Coiled coil coactivator protein antibody
    • Coiled coil leucine zipper coactivator 1 antibody
    • Coiled coil transcriptional coactivator antibody
    • Inorganic pyrophosphatase activator antibody
    • KIAA1536 antibody
    • PP13275 antibody
    • Sarcoma antigen NY-SAR-3 antibody
    see all

Images

  • Anti-CoCoA antibody (ab167237) at 1 µg/ml + Rat brain tissue lysate at 50 µg

    Secondary
    Goat anti-Mouse IgG HRP
    at 1/2500 dilution

    Predicted band size: 77 kDa

  • All lanes : Anti-CoCoA antibody (ab167237) at 1 µg/ml

    Lane 1 : CoCoA transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    Lane 1 : Goat anti-Mouse IgG HRP

    Lane 2 : Goat anti-Mouse IgG HRP
    at 1/2500 dilution

    Predicted band size: 77 kDa

References

ab167237 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab167237.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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