Overview

  • Product name
  • Description
    Rabbit polyclonal to COG7
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 7-246 of Human COG7 (P83436).

  • Positive control
    • HeLa membrane cell lysate; HeLa cells.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 86 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Required for normal Golgi function.
  • Involvement in disease
    Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
  • Sequence similarities
    Belongs to the COG7 family.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CDG2E antibody
    • COG complex subunit 7 antibody
    • cog7 antibody
    • COG7_HUMAN antibody
    • Component of oligomeric Golgi complex 7 antibody
    • Conserved oligomeric Golgi complex component 7 antibody
    • Conserved oligomeric Golgi complex subunit 7 antibody
    see all

Images

  • Anti-COG7 antibody (ab126183) at 1/1000 dilution + HeLa membrane lysate at 20 µg

    Predicted band size : 86 kDa
  • ab126183, at 1/500 dilution, staining COG7 in methanol-fixed HeLa cells by Confocal immunofluorescence (green). Alpha-tubulin filaments are stained in red.

References

ab126183 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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