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Rabbit polyclonal to COG7
Recombinant fragment, corresponding to a region within amino acids 7-246 of Human COG7 (P83436).
HeLa membrane cell lysate; HeLa cells.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate) Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol
Concentration information loading...
Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 86 kDa.
1/100 - 1/1000.
Required for normal Golgi function.
Involvement in disease
Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Belongs to the COG7 family.
Golgi apparatus membrane.
Information by UniProt
COG complex subunit 7 antibody
Western blot - Anti-COG7 antibody (ab126183)
Anti-COG7 antibody (ab126183) at 1/1000 dilution + HeLa membrane lysate at 20 µg
Predicted band size : 86 kDa
Immunocytochemistry/ Immunofluorescence - Anti-COG7 antibody (ab126183)
ab126183, at 1/500 dilution, staining COG7 in
methanol-fixed HeLa cells by Confocal immunofluorescence (green). Alpha-tubulin filaments are stained in red.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"