Overview

  • Product name
    Anti-COL19A1 antibody
  • Description
    Rabbit polyclonal to COL19A1
  • Tested applications
    Suitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: VTVRDKTEES CPILRIEGHQ LTYDNINKLE VSGFDLGDSF SLRRAFCESD KTCFKLGSAL LIRDTIKIFP KGLPEEYSVA AMFRVRRNAK KERWFLWQVL, corresponding to amino acids of Human COL19A1.

  • Positive control
    • Human urinary bladder tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
  • Tissue specificity
    Localized to vascular, neuronal, mesenchymal, and some epithelial basement membrane zones in umbilical cord.
  • Sequence similarities
    Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
    Contains 1 TSP N-terminal (TSPN) domain.
  • Domain
    The numerous interruptions in the triple helix may make this molecule either elastic or flexible.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • COJA1_HUMAN antibody
    • COL19A1 antibody
    • COL9A1L antibody
    • Collagen alpha-1(XIX) chain antibody
    • Collagen alpha-1(Y) chain antibody
    • D6S228E antibody
    see all

Images

  • Immunofluorescent staining of Human cell line A-431 shows positivity in cytoplasm and cell junctions. Recommended concentration of ab122793 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122793, at 1/200 dilution, staining COL19A1 in paraffin-embedded Human urinary bladder tissue by Immunohistochemistry.

References

ab122793 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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