• Product nameAnti-COL1A2 antibody
    See all COL1A2 primary antibodies
  • Description
    Rabbit polyclonal to COL1A2
  • Specificityab72637 detects endogenous levels of fragment of activated COL1A2 resulting from cleavage adjacent to Gly1102.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from human COL1A2.

  • Positive control
    • Extracts from Jurkat cells treated with etoposide (25uM, 24hours).



Our Abpromise guarantee covers the use of ab72637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: 129 kDa).
ELISA 1/10000.


  • FunctionType I collagen is a member of group I collagen (fibrillar forming collagen).
  • Tissue specificityForms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
  • Involvement in diseaseEhlers-Danlos syndrome 7B
    Osteogenesis imperfecta 1
    Osteogenesis imperfecta 2
    Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular form
    Osteogenesis imperfecta 3
    Osteogenesis imperfecta 4
    A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1.
  • Sequence similaritiesBelongs to the fibrillar collagen family.
    Contains 1 fibrillar collagen NC1 domain.
  • DomainThe C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • Post-translational
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha 2 collagen type I antibody
    • Alpha 2 type I collagen antibody
    • Alpha 2 type I procollagen antibody
    • Alpha 2(I) collagen antibody
    • Alpha 2(I) procollagen antibody
    • Alpha-2 type I collagen antibody
    • CO1A2_HUMAN antibody
    • COL1A2 antibody
    • Collagen alpha 2(I) chain antibody
    • Collagen alpha-2(I) chain antibody
    • Collagen I alpha 2 polypeptide antibody
    • Collagen of skin tendon and bone alpha 2 chain antibody
    • Collagen type I alpha 2 antibody
    • OI4 antibody
    • Osteogenesis imperfecta type IV antibody
    • Type I procollagen antibody
    see all

Anti-COL1A2 antibody images

  • All lanes : Anti-COL1A2 antibody (ab72637) at 1/500 dilution

    Lane 1 : Extracts from Jurkat cells treated with etoposide (25µM, 24hours)
    Lane 2 : Extracts from Jurkat cells treated with etoposide (25µM, 24hours) with Cl-peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 129 kDa
    Observed band size : 95 kDa (why is the actual band size different from the predicted?)

References for Anti-COL1A2 antibody (ab72637)

ab72637 has not yet been referenced specifically in any publications.

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