Overview

  • Product nameAnti-Colec12 antibody
    See all Colec12 primary antibodies
  • Description
    Mouse monoclonal to Colec12
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Rat, Cow, Human
  • Immunogen

    Recombinant fragment: AISTNSELST FRSDILDLRQ QLREITEKTS KNKDTLEKLQ ASGDALVDRQ SQLKETLENN SFLITTVNKT LQAYNGYVTN LQQDTSVLQG NLQNQMYSHN, corresponding to amino acids 101-200 of Human Colec12 (AAH60789) with a proprietory tag.

  • Positive control
    • Recombinant tagged human Colec12 fragment.

Properties

Applications

Our Abpromise guarantee covers the use of ab77677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 82 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionScavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
    • Tissue specificityExpressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
    • Sequence similaritiesContains 1 C-type lectin domain.
      Contains 3 collagen-like domains.
    • Cellular localizationMembrane. Forms clusters on the cell surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • CL P1 antibody
      • CL-P1 antibody
      • CLP1 antibody
      • COL12_HUMAN antibody
      • COLEC 12 antibody
      • colec12 antibody
      • Collectin placenta 1 antibody
      • Collectin placenta protein 1 antibody
      • Collectin sub family member 12 antibody
      • Collectin-12 antibody
      • hCL P1 antibody
      • hCL-P1 antibody
      • NSR2 antibody
      • Nurse cell scavenger receptor 2 antibody
      • SCARA4 antibody
      • Scavenger receptor class A member 4 antibody
      • Scavenger receptor with C type lectin antibody
      • Scavenger receptor with C-type lectin antibody
      • SRCL antibody
      see all

    Anti-Colec12 antibody images

    • Anti-Colec12 antibody (ab77677) at 1 µg/ml + Recombinant tagged human Colec12 fragment at 0.2 µg

      Secondary
      Goat anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

      Predicted band size : 82 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    References for Anti-Colec12 antibody (ab77677)

    ab77677 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab77677.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"