Anti-Colec12 antibody - N-terminal (ab173958)

Overview

  • Product name
    Anti-Colec12 antibody - N-terminal
    See all Colec12 primary antibodies
  • Description
    Rabbit polyclonal to Colec12 - N-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Synthetic peptide within Human Colec12 aa 70-100 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q5KU26

  • Positive control
    • MDA-MB453 cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab173958 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 82 kDa.

Target

  • Function
    Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
  • Tissue specificity
    Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
  • Sequence similarities
    Contains 1 C-type lectin domain.
    Contains 3 collagen-like domains.
  • Cellular localization
    Membrane. Forms clusters on the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • CL P1 antibody
    • CL-P1 antibody
    • CLP1 antibody
    • COL12_HUMAN antibody
    • COLEC 12 antibody
    • colec12 antibody
    • Collectin placenta 1 antibody
    • Collectin placenta protein 1 antibody
    • Collectin sub family member 12 antibody
    • Collectin-12 antibody
    • hCL P1 antibody
    • hCL-P1 antibody
    • NSR2 antibody
    • Nurse cell scavenger receptor 2 antibody
    • SCARA4 antibody
    • Scavenger receptor class A member 4 antibody
    • Scavenger receptor with C type lectin antibody
    • Scavenger receptor with C-type lectin antibody
    • SRCL antibody
    see all

Images

  • Anti-Colec12 antibody - N-terminal (ab173958) at 1/100 dilution + MDA-MB453 cell line lysate at 35 µg

    Predicted band size : 82 kDa

References

ab173958 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab173958.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up