Anti-Collagen alpha-5(IV) chain antibody (ab157779)

Overview

  • Product nameAnti-Collagen alpha-5(IV) chain antibody
  • Description
    Rabbit polyclonal to Collagen alpha-5(IV) chain
  • SpecificityReacts with human 161 kDa COL4A5 protein. Cross reacts with proteins from mouse, rat and other species.
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from Cter domain of human COL4A5

Properties

Applications

Our Abpromise guarantee covers the use of ab157779 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/500.
WB 1/500 - 1/2000.

Target

  • FunctionType IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
  • Tissue specificityIsoform 2 is found in kidney.
  • Involvement in diseaseAlport syndrome, X-linked
    Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are found in the chromosome Xq22.3 centromeric deletion syndrome. This results in a phenotype with features of diffuse leiomyomatosis and Alport syndrome (DL-ATS).
  • Sequence similaritiesBelongs to the type IV collagen family.
    Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.
  • DomainAlpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
    The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
  • Cellular localizationSecreted, extracellular space, extracellular matrix, basement membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CO4A5_HUMAN antibody
    • COL4A5 antibody
    • Collagen alpha-5(IV) chain antibody

References for Anti-Collagen alpha-5(IV) chain antibody (ab157779)

ab157779 has not yet been referenced specifically in any publications.

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