Anti-Collagen I + Collagen III antibody (ab36074)

Overview

  • Product nameAnti-Collagen I + Collagen III antibodySee all Collagen I + Collagen III primary antibodies ...
  • Description
    Rabbit polyclonal to Collagen I + Collagen III
  • SpecificityThis antibody showa cross reactivity with: Bovine collagen type III 100%; Bovine collagen type I 100%; Bovine collagen type II <3%; Bovine collagen type IV <1%; Bovine collagen type V <1%; Bovine fibronectin and albumin <0.5%; and Bovine immunoglobulin <0.5%.
  • Tested applicationsELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Cow
  • Immunogen

    Full length native Collagen I + Collagen III proteins (purified) from cow skin.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.1M Sodium chloride, 0.01M Sodium phosphate, 0.01M Sodium borate, pH 7.5, 0.1% mannitol.
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesThis antibody was affinity isolated. It was purified by affinity chromatography on immobilized Collagen I + III.
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab36074 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/2000 - 1/8000.
ICC/IF 1/10 - 1/40.

Target

  • RelevanceCollagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
  • Cellular localizationSecreted
  • Database links
  • Alternative names
    • Alpha 1 type I collagen antibody
    • Alpha 2 type I collagen antibody
    • COL1A1 antibody
    • COL1A1 antibody
    • COL1A2 antibody
    • COL3A1 antibody
    • Collagen fetal antibody
    • Collagen type I alpha 1 antibody
    • Collagen type I alpha 2 antibody
    • Collagen type III alpha 1 antibody
    • EDS4A antibody
    • Ehlers Danlos syndrome type IV autosomal dominant antibody
    • OI4 antibody
    • Type I collagen alpha 1 chain antibody
    • Type I procollagen antibody
    see all

References for Anti-Collagen I + Collagen III antibody (ab36074)

ab36074 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"