Anti-Collagen VI antibody (Biotin) (ab119300)

Overview

  • Product nameAnti-Collagen VI antibody (Biotin)
    See all Collagen VI primary antibodies
  • Description
    Rabbit polyclonal to Collagen VI (Biotin)
  • ConjugationBiotin
  • Tested applicationsSuitable for: WB, IP, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: all Mammals
  • Immunogen

    The immunogen is collagen type VI purified from human and bovine placenta

  • Positive control
    • Human liver or prostate tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab119300 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/10000. Predicted molecular weight: 109 kDa.
IP Use at an assay dependent dilution.
ELISA 1/10000 - 1/50000.
IHC-P Use a concentration of 1.25 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCollagen VI acts as a cell-binding protein.
  • Involvement in diseaseDefects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD) [MIM:254090]; also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
  • Sequence similaritiesBelongs to the type VI collagen family.
    Contains 3 VWFA domains.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha 1 (VI) chain (61 AA) antibody
    • CO6A1_HUMAN antibody
    • COL6A1 antibody
    • COL6A2 antibody
    • COL6A3 antibody
    • Collagen alpha 2(VI) chain antibody
    • Collagen alpha 3(VI) chain antibody
    • Collagen alpha-1(VI) chain antibody
    • Collagen type VI alpha 1 antibody
    • Collagen type VI alpha 2 antibody
    • Collagen type VI alpha 3 antibody
    • Collagen VI alpha 1 polypeptide antibody
    • Collagen VI alpha 2 polypeptide antibody
    • Collagen VI alpha 3 polypeptide antibody
    • CollagenVI antibody
    • Human mRNA for collagen VI alpha 2 C terminal globular domain antibody
    • OPLL antibody
    • PP3610 antibody
    see all

Anti-Collagen VI antibody (Biotin) images

  • ab119300, at a 1.25µg/ml, staining Human Collagen VI in liver, using Immunohistochemistry, Formalin/PFA-fixed parraffin-embedded tissue.
  • ab119300, at a 1.25µg/ml, staining Human Collagen VI in prostate, using Immunohistochemistry, Formalin/PFA-fixed parraffin-embedded tissue.

References for Anti-Collagen VI antibody (Biotin) (ab119300)

ab119300 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding finding biotin labeled primary antibodies and control tissues.

After review of our catalog, my first recommendation is anti-Collagen VI, ab119300. This product is guaranteed in IHC-P and the images on...

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