Anti-Collagen VII antibody [2Q636] (ab64566)

Overview

  • Product nameAnti-Collagen VII antibody [2Q636]
    See all Collagen VII primary antibodies
  • Description
    Mouse monoclonal [2Q636] to Collagen VII
  • Specificityab64566 recognizes carboxy terminal peptide of type VII collagen.
  • Tested applicationsSuitable for: ELISA, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Collagen type VII

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 40% for extra stability and aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.1% Sodium Azide
  • Concentration information loading...
  • PurityAscites
  • ClonalityMonoclonal
  • Clone number2Q636
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab64566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
IHC-Fr Use at an assay dependent dilution.

Target

  • FunctionStratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
  • Involvement in diseaseEpidermolysis bullosa acquisita (EBA) is an autoimmune acquired blistering skin disease resulting from autoantibodies to type VII collagen.
    Epidermolysis bullosa dystrophica, autosomal dominant
    Epidermolysis bullosa dystrophica, autosomal recessive
    Epidermolysis bullosa dystrophica, Pasini type
    Epidermolysis bullosa dystrophica, Hallopeau-Siemens type
    Transient bullous dermolysis of the newborn
    Epidermolysis bullosa dystrophica, pretibial type
    Epidermolysis bullosa dystrophica, Bart type
    Epidermolysis bullosa pruriginosa
    Nail disorder, non-syndromic congenital, 8
    Epidermolysis bullosa dystrophica, with subcorneal cleavage
  • Sequence similaritiesContains 1 BPTI/Kunitz inhibitor domain.
    Contains 9 fibronectin type-III domains.
    Contains 2 VWFA domains.
  • Post-translational
    modifications
    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alpha 1 type VII collagen antibody
    • CO7A1_HUMAN antibody
    • Col7a1 antibody
    • Collagen alpha 1(VII) chain antibody
    • Collagen alpha-1(VII) chain antibody
    • Collagen type VII alpha 1 antibody
    • Collagen VII alpha 1 polypeptide antibody
    • CollagenVII antibody
    • EBD 1 antibody
    • EBD1 antibody
    • EBDCT antibody
    • EBR 1 antibody
    • EBR1 antibody
    • LC collagen antibody
    • Long chain collagen antibody
    • Long-chain collagen antibody
    see all

References for Anti-Collagen VII antibody [2Q636] (ab64566)

ab64566 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I can confirm that this product can detect the NC-1 domain. Unfortunately, the epitope sequence has not been identified but is located at the C-terminus.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"