Overview

  • Product nameAnti-COMMD1/MURR1 antibody
    See all COMMD1/MURR1 primary antibodies
  • Description
    Rabbit polyclonal to COMMD1/MURR1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-190 of Human COMMD1/MURR1 (AAH22046.1).

  • Positive control
    • Mouse liver, HepG2, and transfected 293T lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab102794 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 21 kDa.

Target

  • FunctionProposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141).
  • Tissue specificityUbiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta. Down-regulated in cancer tissues.
  • Sequence similaritiesContains 1 COMM domain.
  • Post-translational
    modifications
    Acetylated by EP300 ina stimuli-specific manner; protecting it from XIAP-mediated proteasomal degradation and required for interaction with RElA in response to stress.
    Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation.
  • Cellular localizationNucleus. Cytoplasm. Endosome membrane. Cytoplasmic vesicle. Early endosome. Recycling endosome. Shuttles between nucleus and cytosol. Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins.
  • Information by UniProt
  • Database links
  • Alternative names
    • C2orf5 antibody
    • COMD1 antibody
    • COMD1_HUMAN antibody
    • COMM domain-containing protein 1 antibody
    • COMMD1 antibody
    • Copper metabolism (Murr1) domain containing 1 antibody
    • Copper metabolism domain containing 1 antibody
    • Copper metabolism gene MURR1 antibody
    • Copper metabolism MURR1 domain-containing protein 1 antibody
    • MGC27155 antibody
    • MURR1 antibody
    • Protein Murr1 antibody
    see all

Anti-COMMD1/MURR1 antibody images

  • Anti-COMMD1/MURR1 antibody (ab102794) at 1/500 dilution + Mouse liver tissue lysate at 50 µg

    Predicted band size : 21 kDa
  • Anti-COMMD1/MURR1 antibody (ab102794) at 1/500 dilution + HepG2 cell lysate at 50 µg

    Predicted band size : 21 kDa
  • All lanes : Anti-COMMD1/MURR1 antibody (ab102794) at 1/500 dilution

    Lane 1 : COMMD1/MURR1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 21 kDa

References for Anti-COMMD1/MURR1 antibody (ab102794)

ab102794 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"